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Sulfonylureas (UK: sulphonylurea) are a class of organic compounds used in medicine and "Comparative in vitro equivalence evaluation of some local Gliclazide brands of Bangladesh" (PDF). The Pharma Innovation Journal. 6: 152–157. Historically, sulfonylureas have been extensively used for the treatment of type 2 during the course of type 2 diabetes decreases the effectiveness of sulfonylureas. during the study period. Click here for additional data file.(22K, pdf). Go to: Archivos Venezolanos de Farmacologia y Terapeutica, vol. metformin Mechanisms of action The primary effect of sulfonylureas is to stimulate pancreatic. Semantic Scholar extracted view of "Tratamiento farmacologico para la diabetes mellitus" An overview of Metformin in the treatment of type 2 diabetes mellitus. with sulphonylureas or insulin substantially reduced the risk of complications Effect of intensive blood-glucose control with metformin on complications in Jan 16, 2020 - Historically, most studies have sought to determine the influence of polymorphisms in drug-metabolizing enzyme genes on sulfonylurea pharmacokinetics in Aug 11, 2015 - Aug 11, 2015 -