Solamargine pdf

Solamargine. Reference work entry. 31 Downloads; CAS Registry Number: 20311-51-7 Open image in new window. Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids - Steroidal Alkaloids. SM (solamargine), a common steroidal alkaloid glycoside, inhibits the growth of human colon, prostate and hepatoma cells . Notably, SM enhances TNF (tumour necrosis factor)-induced apoptosis by increasing TNF receptor expression in human lung cancer cells [ 17 , 18 ]. solamargine on inhibition of p65 protein expression, and EP4 protein expression and promoter activity. Finally, exogenous expressed EP4 feedback reversed the effect of solamargine on phosphorylation of Akt and cell growth inhibition. Conclusion: Our results show that solamargine inhibits the growth of human lung cancer cells through inactivation Solamargine is an azaspiro compound, a steroid and an oxaspiro compound. Solamargine has been used in trials studying the treatment of Actinic Keratosis. steroidal alkaloids such as solamargine have been shown to possess such properties [18, 19]. The aim of the study was to assess the in vitro anticancer activity of alkaloid-enriched fractions from S. aculeastrum fruits by deter-mining its cytotoxicity, P-gp inhibition, and effect in combination with doxorubicin. Furthermore, the bio- The effects of solamargine and metformin on the growth of CRPC cells. We stated to examine the effect of solamargine on growth of CRPC cells. We showed that solamargine inhibited the growth of two CRPC cell lines (PC3 and DU145) in the dose-dependent manner with significant effect observed at 6 to 8 ?M for up to 72 h (Fig. 1A). Solamargine substantially reduced cell viability and induced apoptosis in osteosarcoma U2OS cells. In this connection, Solamargine increased the mRNA and protein expressions of p53 and Bax (a pro-apoptotic protein downstream to p53). The expression of Bcl-2 (an anti-apoptotic protein) was also reduced. Lupeol, apigenin and solamargine from Solanum xanthocarpum exhibited anticancer property. Appearance in solamargine-treated cells of chromatin condensation, DNA fragmentation, and a sub-G1 peak in a DNA histogram suggested that solamargine induced cell death by apoptosis [9-11]. Bhutani KK et al. 2010 study shows that steroidal constituents from Figure 1.BEC is a standardized mixture of sugar-bound solasodine. The two main glycoalkaloids are solasonine and solamargine. All of the glycoalkaloids are made up of the steroid solasodine and one or more of the sugars rhamnose, glucose or galactose. Solamargine production could be followed and quantified for a total of 11 generations of this fungus with a titer of ~250-300 ?g l ?1. This study represents one of the first examples where host plant?derived compounds have been demonstrated to be steadily produced by an endophytic fungi in sizeable quantities. Today, it's known that eggplants produce two different glycoalkaloids — alpha-solamargine and alpha-solasonine. These potent glycoalkaloids can be found throughout the eggplant — including in the peel, seeds, and meat. The thing is, eggplant (aka Solanum melongena L.) glycoalkaloids are toxic organic compounds. With this in mind, in the present study we evaluated the antiproliferative activity of Solanum lycocarpum fruit glycoalkaloid extract (SL) and its major compounds, solamargine (SM) and solasonine (SS), against different tumor cell lines: murine melanoma (B16F10), human colon carcinoma (HT29), human breast adenocarcinoma (MCF-7), human cervical With this in mind, i