Platelet function assay pdf writer

The lab report may look similar to the following: Platelet Response ASPIRIN 400 ARU See Below (1) (1) Test results are reported in Aspirin Reaction Units (ARU). ? 549 ARU - therapeutic range for platelet function. ? 550 ARU - NON-therapeutic range for platelet function. automated, platelet function defects are more dif?cult to diagnose because there are no de?nitive screening tests. Indeed, no current or future platelet function test is likely to be a 100% sensi-tive, due to the large number and variety of platelet defects. The current evaluation of a po-tential platelet defect usually involves platelet ), these ingredients function as skin-conditioning agents - miscellaneous. 1 (Table 1) These adenosine ingredients are structurally similar to one another, naturally-occurring in the human body , and are involved in biological processes including neurotransmission, muscle contraction, cardiac function, platelet function, vasodilation, Laboratory Tests of Platelet Function H. JAMES DAY, M.D. and HOLM HOLMSEN, Ph.D. Hematology Laboratories, Temple University School of Medicine Philadelphia, PA 19140 Introduction There has been growing interest in the role of platelets in the hemostatic process. Following injury to the blood vessel wall, the platelets are exposed to some substance The PFA-100 ® System measures the complex process of primary hemostasis and aids in the rapid detection of platelet dysfunction. It is the first commercially available in vitro testing system to incorporate high-shear flow in which the process of platelet adhesion and aggregation following a vascular injury is simulated in-vitro. Platelet Function Analyzer (PFA-100®): - PFA-100® uses whole blood to measure platelet function under high shear flow conditions. - Sample collected in 3.2% sodium citrate. - Whole blood passes through opening cut into coated membrane. o Membrane coated with collagen and epinephrine or collagen and ADP as agonists. The platelet, of growing practical clinical importance in hemostatic considerations and a variety of medical/surgical processes is also fundamental to etiologic considerations of arteriosclerotic 3 and malignant disease. 4 Order 115345 for citrated platelet count.. Careful estimate of platelet number from stained peripheral blood smear can provide useful information. for platelet function to be restored11, however, 2012 STS Guidelines12 recommend using platelet function testing to aid in timing of surgery, instead of arbitrarily waiting a pre-specified period of time. Conditions that May Affect Test Results: • Patient's exposure to GP IIb/IIIa inhibitors within 48 hours of eptifibatide (Integrilin®), or EDUCATIONAL COMMENTARY - PLATELET FUNCTION TESTS AND ASPIRIN INHIBITION (cont.) Definitive Tests The "gold standard" test for platelet function is the platelet aggregation test using platelet-rich plasma (PRP).5,6 This test is usually performed in a special coagulation laboratory. It is time-consuming and requires strict adherence to protocol. Despite these early observations, for the majority of the 20 th century the only means of assessing platelet function were a small number of fairly unreliable tests (eg, manual platelet count, inspection of the peripheral blood smear, bleeding time). Patients were eligible for inclusion if they were 18 years of age or older, had documented antiplatelet therapy, a VerifyNow P2Y12 platelet function test, and underwent a recent NV procedure. Patient