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A comprehensive guide to side effects including common and rare side effects when taking Aricept (Donepezil Hydrochloride) includes uses, warnings, and drug Jump to ChE inhibitors and cholinergic adverse events - Jump to Adverse effects - Side Effects. Nausea, vomiting, diarrhea, loss of appetite/weight loss, dizziness, drowsiness, weakness, trouble sleeping, shakiness (tremor), or muscle cramps may occur as your body adjusts to the drug.