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Jan 1, 2020 - Interrupt CAMPTOSAR and reduce subsequent doses if severe diarrhea occurs [see Dosage and Administration (2.2) and Warnings and Precautions (5.1)]. Nov 15, 2010 - Keywords: chemotherapy-induced diarrhea, frequency, irinotecan, loperamide, octreotide, leading to the approval of a genotyping method ties. Complete DPD deficiency is extremely rare, but a partial deficiency is present in 3—5% of all. One dosage regimen for loperamide is 4 mg at the first onset of late diarrhea and then 2 mg every 2 hours until the patient is diarrhea-free for at least 12 hours. Interrupt CAMPTOSAR and reduce subsequent doses if severe diarrhea occurs. Table 1. Combination-Agent Dosage Regimens and Dose Modifications a.diarrhea, you do not need any more medication. Take 2 tablets by mouth at the first sign of diarrhea. If you DO have more diarrhea Camptosar/Irinotecan. Irinotecan (Camptosar®). (“eye rye no TEE kan”). Loperamide (Imodium A-D®) Instructions. • Take 4 mg (2 pills) the first time you have diarrhea. • Loperamide Keywords:chemotherapy-induced diarrhea, frequency, irinotecan, loperamide, octreotide, leading to the approval of a genotyping method ties. Complete DPD deficiency is extremely rare,. but a partial deficiency is present in 3 5% of all. Keywords:chemotherapy-induced diarrhea, frequency, irinotecan, loperamide, octreotide, leading to the approval of a genotyping method ties. Complete DPD deficiency is extremely rare,. but a partial deficiency is present in 3 5% of all.